Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.

Sun, Tingting; Aceto, Nicola; Meerbrey, Kristen L; Kessler, Jessica D; Zhou, Chunshui; Migliaccio, Ilenia; Nguyen, Don X; Pavlova, Natalya N; Botero, Maria; Huang, Jian; Bernardi, Ronald J; Schmitt, Earlene; Hu, Guang; Li, Mamie Z; Dephoure, Noah; Gygi, Steven P; Rao, Mitchell; Creighton, Chad J; Hilsenbeck, Susan G; Shaw, Chad A; Muzny, Donna; Gibbs, Richard A; Wheeler, David A; Osborne, C Kent; Schiff, Rachel; Bentires-Alj, Mohamed; Elledge, Stephen J; Westbrook, Thomas F.

Cell ; 144(5): 703-18, 2011 Mar 04.

Artigo em Inglês | MEDLINE | ID: mdl-21376233

2.

Epigenetic markers and therapeutic targets for metastasis.

Kravitz, Carolyn J; Yan, Qin; Nguyen, Don X.

Cancer Metastasis Rev ; 42(2): 427-443, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37286865

3.

Tumor self-seeding by circulating cancer cells.

Kim, Mi-Young; Oskarsson, Thordur; Acharyya, Swarnali; Nguyen, Don X; Zhang, Xiang H-F; Norton, Larry; Massagué, Joan.

Cell ; 139(7): 1315-26, 2009 Dec 24.

Artigo em Inglês | MEDLINE | ID: mdl-20064377

4.

WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.

Nguyen, Don X; Chiang, Anne C; Zhang, Xiang H-F; Kim, Juliet Y; Kris, Mark G; Ladanyi, Marc; Gerald, William L; Massagué, Joan.

Cell ; 138(1): 51-62, 2009 Jul 10.

Artigo em Inglês | MEDLINE | ID: mdl-19576624

5.

Genes that mediate breast cancer metastasis to the brain.

Bos, Paula D; Zhang, Xiang H-F; Nadal, Cristina; Shu, Weiping; Gomis, Roger R; Nguyen, Don X; Minn, Andy J; van de Vijver, Marc J; Gerald, William L; Foekens, John A; Massagué, Joan.

Nature ; 459(7249): 1005-9, 2009 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-19421193

6.

Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway.

Colavito, Sierra A; Zou, Mike R; Yan, Qin; Nguyen, Don X; Stern, David F.

Breast Cancer Res ; 16(5): 444, 2014 Sep 25.

Artigo em Inglês | MEDLINE | ID: mdl-25252859

7.

ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts.

Hu, Bomiao; Wiesehöfer, Marc; de Miguel, Fernando J; Liu, Zongzhi; Chan, Lok-Hei; Choi, Jungmin; Melnick, Mary Ann; Arnal Estape, Anna; Walther, Zenta; Zhao, Dejian; Lopez-Giraldez, Francesc; Wurtz, Anna; Cai, Guoping; Fan, Rong; Gettinger, Scott; Xiao, Andrew; Yan, Qin; Homer, Robert; Nguyen, Don X; Politi, Katerina.

Cancer Res ; 84(8): 1303-1319, 2024 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-38359163

8.

Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations.

Habowski, Amber N; Budagavi, Deepthi P; Scherer, Sandra D; Aurora, Arin B; Caligiuri, Giuseppina; Flynn, William F; Langer, Ellen M; Brody, Jonathan R; Sears, Rosalie C; Foggetti, Giorgia; Arnal Estape, Anna; Nguyen, Don X; Politi, Katerina A; Shen, Xiling; Hsu, David S; Peehl, Donna M; Kurhanewicz, John; Sriram, Renuka; Suarez, Milagros; Xiao, Sophie; Du, Yuchen; Li, Xiao-Nan; Navone, Nora M; Labanca, Estefania; Willey, Christopher D.

Cancers (Basel) ; 16(3)2024 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-38339316

9.

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

Gupta, Gaorav P; Nguyen, Don X; Chiang, Anne C; Bos, Paula D; Kim, Juliet Y; Nadal, Cristina; Gomis, Roger R; Manova-Todorova, Katia; Massagué, Joan.

Nature ; 446(7137): 765-70, 2007 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-17429393

10.

Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer.

de Miguel, Fernando J; Gentile, Claudia; Feng, William W; Silva, Shannon J; Sankar, Akshay; Exposito, Francisco; Cai, Wesley L; Melnick, Mary Ann; Robles-Oteiza, Camila; Hinkley, Madeline M; Tsai, Jeanelle A; Hartley, Antja-Voy; Wei, Jin; Wurtz, Anna; Li, Fangyong; Toki, Maria I; Rimm, David L; Homer, Robert; Wilen, Craig B; Xiao, Andrew Z; Qi, Jun; Yan, Qin; Nguyen, Don X; Jänne, Pasi A; Kadoch, Cigall; Politi, Katerina A.

Cancer Cell ; 41(8): 1516-1534.e9, 2023 08 14.

Artigo em Inglês | MEDLINE | ID: mdl-37541244

11.

Tracing the origins of metastasis.

Nguyen, Don X.

J Pathol ; 223(2): 195-204, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21125675

12.

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.

Cai, Wesley L; Chen, Jocelyn Fang-Yi; Chen, Huacui; Wingrove, Emily; Kurley, Sarah J; Chan, Lok Hei; Zhang, Meiling; Arnal-Estape, Anna; Zhao, Minghui; Balabaki, Amer; Li, Wenxue; Yu, Xufen; Krop, Ethan D; Dou, Yali; Liu, Yansheng; Jin, Jian; Westbrook, Thomas F; Nguyen, Don X; Yan, Qin.

Elife ; 112022 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-36043466

13.

Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.

Adua, Sally J; Arnal-Estapé, Anna; Zhao, Minghui; Qi, Bowen; Liu, Zongzhi Z; Kravitz, Carolyn; Hulme, Heather; Strittmatter, Nicole; López-Giráldez, Francesc; Chande, Sampada; Albert, Alexandra E; Melnick, Mary-Ann; Hu, Bomiao; Politi, Katerina; Chiang, Veronica; Colclough, Nicola; Goodwin, Richard J A; Cross, Darren; Smith, Paul; Nguyen, Don X.

Nat Commun ; 13(1): 7690, 2022 12 12.

Artigo em Inglês | MEDLINE | ID: mdl-36509758

14.

Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.

Karz, Alcida; Dimitrova, Maya; Kleffman, Kevin; Alvarez-Breckenridge, Christopher; Atkins, Michael B; Boire, Adrienne; Bosenberg, Marcus; Brastianos, Priscilla; Cahill, Daniel P; Chen, Qing; Ferguson, Sherise; Forsyth, Peter; Glitza Oliva, Isabella C; Goldberg, Sarah B; Holmen, Sheri L; Knisely, Jonathan P S; Merlino, Glenn; Nguyen, Don X; Pacold, Michael E; Perez-Guijarro, Eva; Smalley, Keiran S M; Tawbi, Hussein A; Wen, Patrick Y; Davies, Michael A; Kluger, Harriet M; Mehnert, Janice M; Hernando, Eva.

Pigment Cell Melanoma Res ; 35(6): 554-572, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35912544

15.

Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development.

Arnal-Estapé, Anna; Foggetti, Giorgia; Starrett, Jacqueline H; Nguyen, Don X; Politi, Katerina.

Cold Spring Harb Perspect Med ; 11(12)2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34518338

16.

Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale.

Morrow, Jon S; Gershkovich, Peter; Gibson, Joanna; Gilshannon, Margaret; Kowalski, Diane; Levi, Angelique W; Nguyen, Don X; Rimm, David L; Xu, Mina L; Sinard, John.

Acad Pathol ; 8: 23742895211047985, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34646939

17.

Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs.

Colclough, Nicola; Chen, Kan; Johnström, Peter; Strittmatter, Nicole; Yan, Yumei; Wrigley, Gail L; Schou, Magnus; Goodwin, Richard; Varnäs, Katarina; Adua, Sally J; Zhao, Minghui; Nguyen, Don X; Maglennon, Gareth; Barton, Peter; Atkinson, James; Zhang, Lin; Janefeldt, Annika; Wilson, Joanne; Smith, Aaron; Takano, Akihiro; Arakawa, Ryosuke; Kondrashov, Mikhail; Malmquist, Jonas; Revunov, Evgeny; Vazquez-Romero, Ana; Moein, Mohammad Mahdi; Windhorst, Albert D; Karp, Natasha A; Finlay, M Raymond V; Ward, Richard A; Yates, James W T; Smith, Paul D; Farde, Lars; Cheng, Zack; Cross, Darren A E.

Clin Cancer Res ; 27(1): 189-201, 2021 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-33028591

18.

Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain.

Cai, Wesley L; Greer, Celeste B; Chen, Jocelyn F; Arnal-Estapé, Anna; Cao, Jian; Yan, Qin; Nguyen, Don X.

BMC Med Genomics ; 13(1): 33, 2020 03 06.

Artigo em Inglês | MEDLINE | ID: mdl-32143622

19.

Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6.

Arnal-Estapé, Anna; Cai, Wesley L; Albert, Alexandra E; Zhao, Minghui; Stevens, Laura E; López-Giráldez, Francesc; Patel, Kiran D; Tyagi, Siddhartha; Schmitt, Earlene M; Westbrook, Thomas F; Nguyen, Don X.

Oncogene ; 39(18): 3726-3737, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32157212

20.

Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy.

Tran, Thuy T; Mahajan, Amit; Chiang, Veronica L; Goldberg, Sarah B; Nguyen, Don X; Jilaveanu, Lucia B; Kluger, Harriet M.

J Immunother Cancer ; 7(1): 200, 2019 07 30.

Artigo em Inglês | MEDLINE | ID: mdl-31362777

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